健脾柔肝汤治疗慢性肝炎肝纤维化临床研究

The Clinical Curative Effect Of Jianpirougan Decoction In The Treatment Of Chronic Hepatitis B Liver Fibrosis

目的:观察健脾柔肝汤治疗慢性肝炎肝纤维化的临床疗效。方法:将60例患者随机均分为治疗组和对照组,两组治疗均采用西药保肝对症疗法,治疗组加用健脾柔肝汤治疗。观察治疗前后肝纤维化血清4项(PCⅢ、HA、LN、Ⅳ-C)及免疫功能变化及不良反应。结果:中医证候疗效比较,治疗组与对照组有效率分别为83.3%、60.0%(P<0.05)。治疗组对肝纤维化血清4项的治疗后复常率显著优于对照组(P<0.01)。治疗组治疗后T淋巴细胞亚群比值升高,CD+8降低(P<0.05),对照组治疗前后上述指标比较,差异无显著性(P>0.05)。结论:健脾柔肝汤能减轻肝组织内部肝纤维化增生,并有促肝细胞再生作用,提高机体免疫功能,从而达到抗纤维化作用。

Objective ： To observe the clinical curative effect of jianpirougan decoction in the treatment of chronic hepatitis B liver fibrosis. Methods： 60 cases were randomly divided into the treatment group and control group on average, two groups were treated by western medicine with protecting liver, treatment group were added jianpirougan tang . Observe liver fibrosis PC III serum 4, HA, LN, IV - C before and after the treatment and the immune function changes and adverse reaction. Results ： The curative effect of TCM syndrome, the effective rate of treatment group and control group was respectively 83.3% , 60.0% （ P 〈 0.05 ）. Treatment group of liver fibrosis was significantly better than control group often rate （P 〈 0.01 ）. After the treatment group therapy T lymphocyte subsets ratio increases, CD8 ＋ （P 〈 0. 05 ） before and after the treatment group, the comparison, there was no significant difference （ P 〉 0.05 ）. Conclusion ：Jianpirougan can reduce the liver tissue inside liver fibrosis, and promote hyperplasia of liver cell regeneration function, imorove the immune function, achieve anti fibrosis.