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Ⅱ相代谢酶基因多态性与肿瘤易感性

Phase Ⅱ metabolic enzyme gene polymorphism and risk of cancer
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摘要 Ⅱ相代谢酶是催化外源性物质在体内进行生物转化的重要代谢酶，其功能强弱可以影响机体对外源性致癌物质的代谢和解毒能力。多种Ⅱ相代谢酶被证实具有基因多态性，且病因学研究结果表明由于代谢酶基因多态性的存在，使暴露于相同环境致癌因素的个体对肿瘤的易感性不同。 Phase Ⅱ metabolic enzymes play pivotal role in the biotransform and metabolism of exoge- nous substances, which might influence its ability of metabolism and detoxification to exogenous carcinogens. Polymorphism have been demonstrated in various phase Ⅱ metabolic enzymes and etiology studies showed that individuals exposed to the same environment could develop different susceptibility to tumorigenesis due to different metabolic enzyme polymorphism. phism on the risk of cancer.
作者 纪健(综述) 李楠(综述) 苑林宏(审校) 肖荣(审校)
机构地区 首都医科大学基础医学院
出处 《国际肿瘤学杂志》 CAS 2010年第11期806-809,共4页 Journal of International Oncology
关键词 多态性 基因 肿瘤 Ⅱ相代谢酶 Polymorphism Here, we summarized the effects of phase Ⅱ metabolic enzyme polymorGene Neoplasms Phase Ⅱ metabolic enzyme
分类号 R734.203 [医药卫生—肿瘤]
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参考文献18

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国际肿瘤学杂志
2010年 第11期

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