多药耐药相关蛋白7及其抑制剂

Multidrag resistance associated protein 7 and its inhibitors

多药耐药（MDR）的机制与转运蛋白有关，现在研究最多的为P-糖蛋白（P-gp）、多药耐药相关蛋白（MRP）1、乳腺癌耐药相关蛋白（BCRP）等的抑制剂。MRP7可介导对紫杉醇、长春新碱和长春碱等的耐药。MRtr7抑制剂近年研究主要包括千斤藤素、酪氨酸酶抑制剂、环孢素A等，MDR是多种机制共同作用的结果，对其他转运体的研究会提供更全面、更广泛的MDR逆转途径。

Mechanism of reversing multidrug resistance （MDR） is associated with transport proteins. Up to date, researches mainly concern P-glycoprotein （P-gp） multidrug resistance associated protein 1 （MRP1）, breast cancer resistance protein （BCRP） inhibitors. Muhidrug resistance associated protein 7 （MRP7） is one of ABC transporters , which belongs to multidrug resistance associated protein （MRP） subfami- ly. A certain number of studies have been conducted in recent years about it , however , they are relatively less than studies on P-GP,MRP1 and BCRP, et al. Structure of MRF7 has certain differences compared with that of other MRPs, and MRP7 mediates drug resistance to paclitaxel, vincristine,taxancs, etc. In recent years reported inhibitors include cepharanthine tyrosine kinase inhibitors ,cyclosporine A, et al. MDR results from a variety of mechanisms so that researches on other transporters may provide extensive ways to reverse MDR.