摘要
以小分子干扰RNA(siRNA)为中心的RNA干扰(RNAi)技术因其高度序列特异性、高效性、作用迅速等特点,越来越来成为恶性肿瘤基因治疗的研究热点。近年来多项研究表明,构建并导入靶向头颈恶性肿瘤相关基因特异siRNA,可以有效地抑制肿瘤的增殖、侵袭,联合其他常规治疗手段可以提高疗效,是头颈肿瘤的基因治疗领域颇有前景的新方法。
RNA interference which focuses on siRNA becomes a studying focus in malignant tumor of gene therapy due to its high efficiency and effect, the sequence of specific characteristics and action fast. In re- cent years many research shows that constructing and transfecting malignancy related gene targeting specific siR- NA, can effectively suppress tumor growth and invasion. Combination with other conventional treatments can im- prove the curative effect. It's a promising new method of genc therapy in head and neck neoplasms.
出处
《国际肿瘤学杂志》
CAS
2010年第11期842-845,共4页
Journal of International Oncology