小分子干扰RNA在头颈部肿瘤的研究进展

Research progress of siRNA in head and neck neoplasms

以小分子干扰RNA（siRNA）为中心的RNA干扰（RNAi）技术因其高度序列特异性、高效性、作用迅速等特点，越来越来成为恶性肿瘤基因治疗的研究热点。近年来多项研究表明，构建并导入靶向头颈恶性肿瘤相关基因特异siRNA，可以有效地抑制肿瘤的增殖、侵袭，联合其他常规治疗手段可以提高疗效，是头颈肿瘤的基因治疗领域颇有前景的新方法。

RNA interference which focuses on siRNA becomes a studying focus in malignant tumor of gene therapy due to its high efficiency and effect, the sequence of specific characteristics and action fast. In re- cent years many research shows that constructing and transfecting malignancy related gene targeting specific siR- NA, can effectively suppress tumor growth and invasion. Combination with other conventional treatments can im- prove the curative effect. It＇s a promising new method of genc therapy in head and neck neoplasms.