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ClC-3氯离子通道与肿瘤 被引量：1

ClC-3 chloride channel and tumors
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摘要 ClC-3氯离子通道的功能主要是调节细胞容积和保持胞内囊泡腔电中性,是正常细胞生长和增殖必不可少的元件。近年研究发现ClC-3也与肿瘤的发生和发展密切相关,其在肿瘤组织中呈高表达,在肿瘤细胞周期和凋亡的调控以及细胞迁移等过程中扮演了重要的角色,有望成为抗肿瘤新靶点。 ClC-3 chloride channel is essential for normal cell growth and proliferation.It mainly functions as a regulator for cell volume and ion homeostasis.It has been shown that ClC-3 is involved in tumor formation and development.It is highly expressed in tumor tissues and plays key role in tumor cell cycle,apoptosis and migration,suggesting that ClC-3 may be a promising target for tumor therapy.
作者 武晓英 毛建文 李红枝
机构地区 广东药学院生物学教研室
出处 《国际病理科学与临床杂志》 CAS 2010年第5期392-396,共5页 Journal of International Pathology and Clinical Medicine
基金 国家自然科学基金(30800435) 广东省医学科研基金(B2008086)~~
关键词 ClC-3氯离子通道 肿瘤 细胞周期 细胞迁移 细胞凋亡 ClC-3 chloride channel tumor cell cycle cell migration cell apoptosis
分类号 R730.2 [医药卫生—肿瘤]
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  • 1JianWenMAO,LiWeiWANG,TimJACOB,XueRongSUN,HuiLI,LinYanZHU,PanLI,PingZHONG,SiHuaiNIE,LiXinCHEN.Involvement of regulatory volume decrease in the migration of nasopharyn-geal carcinoma cells[J].Cell Research,2005,15(5):371-378. 被引量：9
  • 2孙雪荣,王立伟,毛建文,朱林燕,聂思槐,钟平,陈丽新.人胎儿鼻咽上皮细胞的背景氯电流[J].生理学报,2005,57(3):349-354. 被引量：13
  • 3Yoshikawa M,Uchida S Ezaki J, et al. CLC-3 deficiency leads to pheno-types similar to human neuronal ceroid lipofus2 cinosis[J]. Genes Cells, 2002,7:5972605.
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国际病理科学与临床杂志
2010年 第5期

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