肝细胞肝癌术后预后分子预测模型的研究进展

Advance in research on prognosis and recurrence model for hepatocellular carcinoma

肝细胞肝癌作为世界上第5位常见恶性肿瘤,发病率呈上升趋势,术后转移和复发的比例很高,长期生存率很低。随着对肿瘤转移机制理解的加深,找到了与大量转移和复发相关的分子标志物,可用于预测个体复发和预后危险度,进而指导临床治疗。本综述系统回顾肝癌转移复发分子标志物,对于进一步应用新技术发现和验证分子预测标签,以及寻找更可靠的分子标签和治疗靶标有重要意义。

Hepatocellular carcinoma （HCC） is the fifth common malignant tumor in worldwide.Its incidence ratio was rising.Surgery resection and liver transplants are still the potential tools for HCC therapy.However,after the treatment,the patients show low survival ratio for longtime disease-free,and the percentage of recurrence and metastasis is still very high.With the progress in understanding the mechanism of tumor metastasis,lots of biomarkers for HCC are emerged,which are valuable in the diagnosis,therapy and prognosis prediction for HCC.This review summarized recent progress in the studies on molecular markers for HCC.It is hopefully to provide some clues for seeking novel reliable markers for HCC therapy and prognosis.