摘要
破骨细胞和成骨细胞分别介导骨的吸收过程和合成过程,而OPG、RANK、RANKL在调节二者的比例中发挥非常重要的作用。RANKL与RANK结合后可能通过三种途径:JNK途径、NF-κB途径和蛋白激酶B途径参与破骨细胞的分化,促进骨质的吸收;RANKL与OPG结合后能阻断RANKL与RANK的结合,由于缺乏RANKL-RANK产生的转录活化信号,破骨细胞分化成熟发生障碍,骨质的吸收受到抑制。OPG、RANK、RANKL同时也是免疫分子,在淋巴细胞、淋巴器官的分化、发育中起重要的作用,骨疾病与免疫系统之间存在着一定的关系。RANKL/RANK与RANKL/OPG在生物体内保持着一定的比率,如果比率失衡,就会引起各种骨疾病。本篇综述总结了近年来OPG、RANK、RANKL结构、作用的新进展以及它们在骨疾病中的作用。
Osteoclast regulates bone resorption and osteoblast is important in bone composition, and OPG ＆ RANK ＆ RANKL play an important role in the regulation of their ratio. RANKL combined with RANK to be concerned with osteoclast differentiation, which promote bone resorption; however, RANKL combined with OPG to inhibit osteoclast developing, which inhibit bone resorption. There is some ratio between RANKL/RANK and RANKL/OPG. If the ratio loses its balance, living organism will get some bone disease. At the same time OPG ＆ RANK ＆ RANKL are immunology molecules . It was reported that bone diseases have some connections with immunology system. This review considers recent advances in knowledge about structure and mechanism of OPG ＆ RANK ＆ RANKL and their effect on bone diseases.
出处
《现代生物医学进展》
CAS
2010年第20期3963-3966,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金资助项目(10672015)
