扶正祛邪法对肺癌患者免疫功能及血清可溶性Fas凋亡抵抗的影响

Effect of Therapy of Supporting Healthy Qi and Dispelling Pathogenic Qi on Immune Function and Serum Soluble Fas Apoptosis Resistance in Lung Cancer Patients

【目的】观察扶正祛邪法对痰瘀互结证肺癌患者的免疫功能及血清可溶性Fas(sFas)凋亡抵抗的影响。【方法】将76例痰瘀互结证非小细胞肺癌患者随机分为2组。对照组38例采用吉西他滨/顺铂(GP)方案化疗,4周为1个周期,治疗6个周期;治疗组38例则在GP方案化疗的基础上加用肺癌合剂,2个月为1个疗程,共治疗3个疗程。对比观察2组治疗前后肺癌患者免疫功能及血清sFas凋亡抵抗的影响。【结果】治疗后治疗组的CD3、CD4、CD4/CD8比值及自然杀伤(NK)细胞均高于对照组(P<0.05或P<0.01);而血清sFas水平显著低于对照组(P<0.01)。【结论】扶正祛邪法中药制剂不但可以减轻化疗对肺癌患者免疫系统的损伤,提高肺癌患者的免疫功能,还可以抑制肿瘤细胞的凋亡抵抗。

Objective To observe the effect of therapy of supporting healthy Qi and dispelling pathogenic Qi on immune function and serum soluble Fas （sFas） apoptosis resistance in lung cancer patients. Methods Seventy-six non-small-cell lung cancer patients with phlegm blended with blood stasis were equally randomized into the treatment group and the control group. The two groups received the regimen of gemcitabine/platinol （GP） chemotherapy, 4 weeks constituted one treatment course, and the treatment lasted 6 courses. The treatment group received Lung Cancer Mixture on the basis of GP regimen, 2 months constituted one treatment course, and the treatment lasted 3 courses. The changes of immune function and serum sFas apoptosis resistance in two groups were observed before and after treatment. Results After treatment, the percentages of CD3 and CD4, CDJCDs ratio and the number of natural killer （NK） cells were higher （P 〈0. 05 or P 〈0.01 ） , but serum sFas level was lower in the treatment group than those in the control group （P 〈 0.01 ）. Conclusion Chinese herbal medicinal prescriptions, which have the actions of supporting healthy Qi and dispelling pathogenic Qi, can improve the immune function and inhibit the tumor cell apoptosis resistance in lung cancer patients.