谷胱甘肽S转移酶T1基因多态性与口腔癌易感性的meta分析

Association between GSTT1 gene polymorphisms and risk of oral cancer:a meta analysis

目的:通过既往相关研究,综合评价谷胱甘肽S转移酶T1(glutathione S-transferase class Theta-1,GSTT1)基因多态性与口腔癌易感性间的关联。方法:根据系统评价的原理和规范,检索PubMed数据库,纳入GSTT1基因与口腔癌的病例对照研究。根据种族,采用分层Meta分析评估GSTT1基因多态性与口腔癌的关联性,同时评估发表偏倚。结果:Meta分析显示,GSTT1基因多态性与口腔癌总的效应为OR=1.17(95%CI:0.87～1.58)。进一步亚组分析显示,亚洲人种OR=0.99(95%CI:0.71～1.36);高加索人种OR=1.07(95%CI:0.69～1.64);混合人种OR=1.89(95%CI:0.76～4.67)。结论:尚不能认为GSTT1基因多态性能影响口腔癌的易感性,这一结论尚需要大规模、多种族的流行病学或功能学研究验证。

Objective：To evaluate the relationship between glutathione S-transferase class Theta-1 （GSTT1） gene polymorphisms and oral Cancer.Methods：According to the theory and principles of systematic review,data from case-control studies regarding the association between GSTT1 gene polymorphisms and oral cancer were derived through electronic search of PubMed.To gain a more precise estimation of the relationship,a stratified meta-analysis with three subgroups was performed according to the races.Publication bias was also assessed by chi-square based Q test.Results：The overall effect between GSTT1 gene polymorphisms and oral cancer was OR=1.17 （95%CI：0.87～1.58）.Furthermore,subgroup analysis were performed according to race.However,no significant effect was found[OR=0.99 （95%CI：0.71～1.36）in Asian;OR=1.07 （95%CI：0.69～1.64）in Caucasian;OR=1.89（95%CI：0.76～4.67）in Mixed race].Conclusion：The association between GSTT1 gene polymorphisms and oral cancer was negative,and further large scale and multi-race epidemiological or biological functional studies were warranted to evaluate the results.