含左氧氟沙星的三联疗法及序贯疗法与传统序贯疗法治疗幽门螺杆菌的疗效比较

A comparison in H.pylori eradication rate among 7-day levofloxacin-based triple therapy,10-day levofloxacin-based sequential regimen and conventional sequential therapy

目的:比较含左氧氟沙星的三联疗法、序贯疗法与传统序贯疗法根治幽门螺杆菌(H.pylori,Hp)的疗效。方法:64例Hp阳性病例,随机分为3组:A组18例予质子泵抑制剂(proton pump inhibitor,PPI)、阿莫西林和左氧氟沙星治疗,疗程7天。B组25例前5天予PPI和阿莫西林,后5天予PPI、克拉霉素和替硝唑。C组21例予含左氧氟沙星的序贯疗法,前5天予PPI、阿莫西林,后5天予PPI、左氧氟沙星及替硝唑。结果:含左氧氟沙星三联疗法Hp根治率为83.33%,标准序贯疗法Hp根治率为84%,含左氧氟沙星序贯疗法Hp根治率为76.19%。结论:含左氧氟沙星的三联疗法、序贯疗法与传统序贯疗法对本地区Hp的根治率没有明显差异。

Objective：To compare the eradication rates of H.pylori among 7-day levofloxacin-based triple therapy,10-day levofloxacin-based sequential regimen and conventional sequential therapy.Methods：The total 64 patients with H.pylori were randomly divided into three groups.Eighteen patients in group A were treated with proton pump inhibitor （PPI）,amoxincillin and levofloxacin for 7 days.Tweenty-five patients in group B were treated with PPI and amoxicillin for 5 days,and then with PPI,clarithromycin and tinida zole for another 5 days.Tweenty-one patients in group C were treated with PPI and amoxicillin for 5 days;and then with PPI,levofloxacin and tinidazole for another 5 days.Results：The eradication rate of 7-day levofloxacin-based triple therapy was 83.33%;the eradication rate of conventional sequential therapy was 84%;and that of 10-day levofloxacin-based sequential regimen was 76.19%.Conclusion：There were no significant difference in eradication rate of H.pylori among 7-day levofloxacin-based triple therapy,10-day levofloxacin-based sequential regimen and conventional sequential therapy.