110例垂体腺瘤经蝶窦显微外科治疗

Transsphenoidal microsurgery of pituitary adenomas

垂体腺瘤是一种常见的颅内肿瘤。近年来由于CT扫描和内分泌测定的进展,使垂体腺瘤可以早期确诊;经蝶窦显微外科的应用,使垂体腺瘤的疗效明显提高,手术死亡率和病残率降低。现将本院自1983年10月至1989年10月经蝶窦显微外科切除的110例垂体腺瘤的结果报道如下。临床资料本组110例垂体腺瘤患者,女78例,男32例,年龄13～66岁,平均33.4岁。病程3个月～14年,平均3年2个月。全部病例均经CT扫描诊断和病理切片证实,部分经放射免疫法内分泌测定和免疫细胞化学染色及电镜观察,按病人的临床表现、X线片、CT扫描、

This paper presents 110 cases of pituitary adenomas diagnosed through CT scanning and radioimmunological hormone assay. Fortyseven microadenomas, 56 macroadenomas and 7 giant adenomas were removed totally, subtotally or partially by means of transsphenoidal microsur- gery. All tumors determined through pathologic examination and immunocytologic stain were composed of 62 PRL adenomas, 11 GH adenomas, 7 ACTH adenomas and 30 nonsecretory adeno- mas. The endocrine function and visual acuity or field were improved markedly after operation without any operative death and severe complications. The operative mortality and morbidity of transsphenoidal microsurgery are evidently lower than those of transfrontal craniotomy.