联合应用止吐药控制高剂量顺铂治疗引起胃肠反应的初步报告

Combined use of anti-emetics to control nausea and vomiting induced by high-dose cis-platin

恶心呕吐是抗肿瘤化疗最常见的副反应之一。常用抗癌药引起胃肠反应的发生率及其严重程度不尽相同,有时可限制化疗药物的使用或增加剂量。因此,寻找有效的止吐方案已成为十分重要的课题,目前已有很多有益的探讨。 1987年12月至1988年8月间,我科对接受高剂量顺铂(HD-DDP)化疗的恶性肿瘤患者进行了联合止吐方案的随机对照研究。进入本组病例共36例,可评价者34例,共79个周期。现将两个联合止吐方案的效果进行比较。

The present study was designed to compare at random the effect of group A therapy (meto- clopramide + dexamethasone + droperidol + valium + diphenhydramum ) with that of group B therapy (metoclopramide + chlorpramidum + dexamethasone ) in the treatment of cis-platin induced nausea and vomiting at the dosage of 50～100 mg/m^2 of cis-platin. Vomiting was observed in 87.9% and 92.1% of the cases treated with group A therapy and group B therapy respectively, but moderate and serious vomiting was observed in 31.7% of the patients treated with group A therapy and in 68.4% with group B therapy. Therefore, the group A therapy seems to be significantly superior to the group B therapy (P<0.01).