依巴斯汀联合雷公藤多苷在慢性荨麻疹治疗中的效果观察

Observation of the Effects on Ebastine Combined with TriperygiumWilfordii Muitiglucoside in the Patients with Chronic Urticaria

目的探讨依巴斯汀联合雷公藤多苷在慢性荨麻疹治疗中的效果。方法选取2008年1月～2010年5月于我院进行治疗的82例慢性荨麻疹患者为研究对象,将其随机分为对照组（依巴斯汀组）41例和观察组（依巴斯汀联合雷公藤多苷组）41例,后将两组患者的治疗总有效率、不良反应发生率及治疗前后的血清总IgE、IL-4、SOD、MDA及NO水平进行检测及比较。结果经研究比较发现,观察组的治疗总有效率明显高于对照组,且观察组的血清总IgE、IL-4、MDA及NO低于对照组,血清SOD高于对照组,经比较,P均〈0.05,均有显著性差异,而两组患者的不良反应发生率无显著性差异,P〉0.05。结论依巴斯汀联合雷公藤多苷在慢性荨麻疹治疗中的效果明显,且较为安全,对调节患者的多项血清因子也有一定的作用,值得临床推广应用。

Objective To study the effects on Ebastine combined with TriperygiumWilfordii Multiglucoside in the patients with chronic urticaria. Methods 82 patients with chronic urticaria in our hospital from January 2008 to May2010 were selected as research object,and they were randomly divided into control group （Ehastine group）41 cases and observation group （Ebastine combined with TriperygiumWilfordii Multiglucoside group）41 cases,and the total effective rate ,incidence of adverse reactions and the serum IgE,IL-4,SOD,MDA and NO before and after the treatment of the two groups were detected and compared.Results According the comparison, the total effective rate of the observation group was higher than that of the control group,and the serum total IgE,IL-4,MDA and NO of the observation group were lower than those of the the control group,but the serum SOD of the observation group was higher than that of the control group,P〈0.05, there were significant differences.But the incidence of adverse reactions of the two groups had no differences, P〉0.05.Conclusion The effects of Ebastine combined with Triperygium Wilfordii Multiglucoside in the patients with chronic urticaria is better, and it is safe, and it play roles for regulating various serum factors, and it is worthy of popularization and application.