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A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population 被引量：5

A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population
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摘要 Objective： Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 （TLR4） gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility to Objective： Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 （TLR4） gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility to
作者 Hua Huang Juan Wu Guangfu Jin Hanze Zhang Yanbing Ding Zhaolai Hua Yan Zhou Yan Xue Yan Lu Zhibin Hu Yaochu Xu Hongbing Shen
机构地区 Department of Epidemiology and Biostatisties Department of Gastroenterology Department of Epidemiology Department of Oneology
出处 《The Journal of Biomedical Research》 CAS 2010年第2期100-106,共7页 生物医学研究杂志（英文版）
基金 supported in part by National Natural Science Foundation of China (30700684 and 30671814) Jiangsu Natural Science Foundation (BK2008221) the Key Project of Nanjing Medical University (09NJMUZ12)
关键词 toll-like receptor 4 POLYMORPHISMS SUSCEPTIBILITY gastric cancer toll-like receptor 4, polymorphisms, susceptibility, gastric cancer
分类号 Q782 [生物学—分子生物学] N031 [自然科学总论—科学技术哲学]
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参考文献10

  • 1Achyut BR,Ghoshal UC,Moorchung N,Mittal B.Association of Toll-like receptor-4(Asp299Gly and Thr399Ileu)gene polymorphisms with gastritis and precancerous lesions[].Human Immunology.2007
  • 2Garza-Gonzalez E,Bosques-Padilla FJ,Mendoza-Ibarra SI,Flores-Gutierrez JP,Maldonado-Garza HJ,Perez-Perez GI.Assessment of the toll-like receptor4Asp299Gly,Thr399Ile and interleukin-8-251polymorphisms in the risk for the development of distal gastric cancer[].BMC Cancer.2007
  • 3Wu J,Lu Y,Ding YB,Ke Q,Hu ZB,Yan ZG,et al.Promoter polymorphisms of IL2,IL4,and risk of gastric cancer in a high-risk Chinese population[].Molecular Carcinogenesis.2009
  • 4Lawrence T.Inflammation and cancer:a failure of resolution?[].Trends in Pharmacological Sciences.2007
  • 5Ferwerda B,McCall MB,Alonso S,Giamarellos-Bourboulis EJ,Mouktaroudi M,Izagirre N,et al.TLR4polymorphisms,infectious diseases,and evolutionary pressure during migration of modern humans[].Proceedings of the National Academy of Sciences of the United States of America.2007
  • 6Child NJ,Yang IA,Pulletz MC,de Courcy-Golder K,Andrews AL,Pappachan VJ,et al.Polymorphisms in Toll-like receptor4and the systemic inflammatory response syndrome[].Biochemical Society Transactions.2003
  • 7Lauren P.The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma-an attempt at a histo-clinical classification[].Acta Pathologica Microbiologica et Immunologica Scandinavica.1965
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The Journal of Biomedical Research
2010年 第2期

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