疣状表皮痣62例临床与病理分析

A Clinicopathological Analysis of 62 Patients with Verrucous Epidermal Nevi

目的探讨疣状表皮痣(verrucous epidermal nevi,VEN)的临床病理特点,提高对本病的认识。方法回顾性分析62例VEN患者的临床和组织病理资料。结果患者发病年龄从出生至29岁,62例患者中局限型29例(46.77%),系统型19例(30.65%),炎症性线状型(ILVEN)14例(22.58%)。局限型和系统型皮损表现为疣状丘疹或斑块,炎症性线状型表现为线状红色瘙痒性斑块。皮损组织病理主要表现为:角化过度、棘层肥厚、乳头瘤样增生和皮突延长,多数病例伴颗粒层增厚,有的病例伴角化不全、表皮松解性角化过度、基底层色素增加以及真皮浅层血管周围淋巴细胞和组织细胞轻度至中度浸润。结论 VEN多发生于出生时和婴儿期,但婴儿期后发病并不少见,且以局限型最为多见。本病皮损具有特征性,组织病理有助于鉴别诊断。

Objective To study the clinicopathological features of verrucous epidermal nevi （VEN） and improve cognition to VEN.Method The clinical and histopathological data of 62 patients with VEN were analyzed retrospectively.Results Age of onset ranged from birth to 29 years.There were 29（46.77%） cases of localized VEN,19（30.65%） cases of systematized VEN and 14（22.58%） cases of inflammatory linear verrucous epidermal nevi （ILVEN）.Localized or systematized VEN usually presented as warty papules or plaques and ILVEN as pruritic,linear,erythematous plaques.Histopathology of all cases revealed hyperkeratosis,acanthosis,papillomatosis and elongation of the rete ridges.Most cases demonstrated hypergranulosis.Some cases showed parakeratosis,epidermolytic hyperkeratosis,and increase of melanin in basal cell layer or mild to moderate superficial perivascular infiltration of lymphocytes and histocytes in the dermis.Conclusions VEN usually presented at birth or infancy,but onset after infancy was not uncommon.The commonest variant of VEN was localized VEN.The disease has characteristic lesions.The histopathology is helpful in its differential diagnosis.