2Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections [J]. Science, 1999, 284(5418)∶1 318-1 322.
3Noiri Y, Ehara A, Kawahara T, et al. Participation of bacterial biofilms in refractory and chronic periapical periodontitis [J]. J Endon, 2002, 28(10)∶679-683.
4Leonardo MR, Rossi MA, Silva LAB, et al. EM evaluation of bacterial biofilm and microorganisms on the apical external root surface of human teeth [J]. J Endon, 2002, 28(12)∶815-818.
5Molven O, Olsen I, Kerekes K. Scanning electron microscopic observations of apical part of root canals in permanent teeth with periapical lesions [J]. Endod Dent Traumatol, 1991,7∶226-229.
6Lomcali G, Sen BH, Cankaya H. Scanning electron microscopic observations of apical root surfaces of teeth with apical periodontitis [J]. Endod Dent Traumatol, 1996, 12(2)∶70-76.
7Tronstad L, Barnett F, Cervone F. Periapical bacterial plaque in teeth refractory to endodontic treatment [J]. Endod Dent Traumatol, 1990, 6(2)∶73-77.
8Park YJ,Lee JY,Yeom HR. Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis[J].{H}Biotechnology Letters,2005,(22):1761-1766.
9Sakellari D, Goodson JM, Kolokotronis A, et al. Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva. J Clin Periodontol, 2000, 27(1):53-60.