三种光疗法治疗寻常性痤疮疗效观察

Effectiveness of three phototherapy in the treatment of acne vulgaris

目的:评价光动力学疗法(PDT),强脉冲光(IPL)和红蓝光(LED)治疗中、重度寻常性痤疮的疗效。方法:将90例中、重度痤疮患者随机分为三组:PDT治疗组,IPL治疗组和LED红蓝光治疗组。分别于治疗前、治疗中期(治疗1个月)和末次治疗结束后评价疗效。结果:治疗中期评价时,PDT、IPL、LED治疗组总有效率分别为93.3%、60.0%和36.7%,平均皮损减少率分别为90.4%、69.0%和39.8%。要达到炎症性皮损痊愈,PDT组平均需要(3±1.52)个治疗周期,IPL组(6±2.15)个治疗周期,LED组(9±3.34)个治疗周期。结论:光疗法治疗中、重度痤疮疗效显著,PDT组疗法效果优于IPL和LED组,副作用少,有很好应用前景,而长期疗效有待进一步观察。

Objective To evaluate the effectiveness of photodynamic therapy （PDT）, intense pulsed light （IPL） and lightemitting diode （LED） phototherapy for the treatment of moderate to severe acne vulgaris. Methods 90 patients with moderate to severe acne were randomly divided into 3 equal groups： ALA-PDT group, IPL group, blue-red combination LED group.Clinical assessments were conducted before starting treatment, at 1 month as a midpoint evaluation, and after the final treatment session. Results At the mid-point evaluation, in case of PDT, IPL and LED groups, the effective rate were 93.3%,60.0%,36.7%,respectively, and the percent reductions were 90.4%,69.0%,39.8%,respectively. Patients treated with the PDT reached a≥90% clearance of their inflammatory lesions after a mean of 3±1.52 sessions, while patients treated with iPL required a mean of 6±2.15 sessions. Patients treated with the LED required a mean of 9± 3.34 sessions. Conclusions Phototherapy is effective treatment option for moderate to severe acne with mild side effects. Effectiveness of PDT is the best in the three group. Validates further studies to evaluate treatments for a longer effectives.