金属蛋白酶9和超敏C反应蛋白与稳定期卒中的相关性

The relationship between matrix metalloproteinase-9, high-sensitivity C-reactive protein and stroke of stable stage

目的 了解缺血性卒中稳定期血基质金属蛋白酶9（MMP-9）和超敏C反应蛋白（hs-CRP）水平及之间的相关性,探讨其可能的临床应用价值.方法 将患者分为卒中复发组（39例）、卒中稳定组（37例）、无症状颅内动脉狭窄组（46例）并设对照组（74例）.收集相关临床资料,检测MMP-9和hs-CRP浓度.结果 hs-CRP水平复发组（2.34 mg/L）＞稳定组（1.45 mg/L）＞无症状狭窄组（1.31 mg/L）＞对照组（0.96 mg/L）（P=0.001）;MMP-9水平复发组（121.82±72.99）μg/L＞无症状狭窄组（119.18±80.01）μg/L＞稳定组（112.76±59.66）μg/L,三组间差异无统计学意义（P=0.947）,比较三组病例组MMP-9平均水平（118.08±71.06）pg/L显著高于对照组[（57.55±10.44）μg/L,P＜0.001];Spearman相关分析显示：MMP-9与hs-CRP之间呈显著正相关（r=0.337,P＜0.001）.结论 hs-CRP在卒中稳定期仍维持较高水平,并与卒中复发相关;而MMP-9与动脉粥样硬化相关性强于卒中事件.

Objective Plasma levels of matrix metalloproteinase-9 （ MMP-9 ） and serum level of high-sensitivity C reactive protein （hs-CRP） were detected to investigate their distributions between patients with stable stroke and those with asymptomatic intracranial artery stenosis and to explore their clinical significance. Methods The mean level of the serum hs-CRP of the group with recurrent stroke （2.34 mg/L）was the highest, followed by that of the group with the stable stroke（ 1.45 mg/L）,asymptomatic intracranial artery stenosis （ 1.31 mg/L） and control group （0.96 mg/L） （ P = 0.001 ）. The level of the MMP-9 was in sequence of recurrent stroke group （ 121.82 ± 72.99 ） μg/L ＞ asymptomaticintracranial artery stenosis group （ 119.18 ± 80.01 ） μg/L ＞ stable stroke group（ 112.76 ± 59.66） μg/L,while no statistical significance was found among groups（ P = 0.947 ）. However, the level of MMP-9 of three patient groups（ 118.08 ± 71.06 ） μg/L was significant higher than control group（ 57.55 ± 10.44 ）μg/L （P ＜0.001 ）. The spearman analysis for the relationship showed that the concentration of MMP-9 was positively associated with that of hs-CRP （ r = 0.337, P ＜ 0.001 ）. Conclusions The hs-CRP maintained a high level in stable stage of stroke. The MMP-9 level in the patients group was significant higher than control group and the level of MMP-9 was positively associated with that of hs-CRP which suggested MMP-9 might be correlated with atherosclerosis other than stroke occurrence.