纳洛酮联合胞磷胆碱治疗重症脑梗死的临床观察

THE CLINICAL OBSERVATION OF SEVERE CEREBRAL INFARCTION CASES TREATED BY NALOXONE COMBINED WITH CITICOLINE

目的观察纳洛酮联合胞磷胆碱治疗重症脑梗死的疗效与安全。方法将64例重症脑梗死患者随机分为2组,对照组在综合治疗的基础上给予胞磷胆碱治疗;治疗组在对照组基础上加用纳洛酮治疗。结果治疗组有效率为93.8%,对照组为65.6%,差异有统计学意义(P<0.01);治疗组与对照组都未见严重不良反应发生。结论纳络酮联合胞磷胆碱作用广泛,安全有效,不良反应小,可逆转重症脑梗死患者连带的继发性脑功能损伤,值得临床推广。

Objective To observe the clinical effects and security of severe cerebral infarction cases treated by naloxone combined with citicoline. Methods Sixty -four cases with severe cerebral infarction were randomly divided into 2 groups, the control group was given citieoline on the basis of comprhensive treatment; The treatment group was given naloxone on the basis of control group treatment, Results The effective rate of the treatment group was 93.8%, while 65.6% in the control group, the difference was statistically significant （ P 〈 0.01 ）. Both the treatment group and control group had no serious adverse events. Conclusion Naloxone combined with eiticoline for treating severe eerobral infarction was extensive, safe and effective, without significant side effects, can reverse the cerebral infarction associated severe secondary brain injury, so it is worthy of promotting.