生姜合剂对运动病大鼠血浆皮质醇水平的影响

INFLUENCE OF COMPOUND GINGER EXTRACTS ON PLASMA CORTISOL LEVEL IN MOTION SICKNESS RATS

本文研究生姜合剂抗运动病时血浆皮质醇水平的变化,以探讨运动病与内分泌功能的关系,为运动病防治提供新的实验依据。方法:以旋转运动诱发大鼠条件性厌食症模拟运动病,用放射免疫法测定此时的血浆皮质醇水平,并观察生姜合剂(灌胃,1.8ml/200g)的抗运动病作用,及对血浆皮质醇水平的影响。结果:模拟运动病时大鼠血浆皮质醇水平有升高趋势,生姜合剂能进一步提高大鼠的血浆皮质醇水平。结论:运动病不是一种单纯的应激反应,运动病的发生可能与异常运动刺激引起机体内分泌功能紊乱有关。

Objective: To observe the change in plasma cortisol level of rats after motion sickness and administration of compound ginger extracts, in order to investigate the relations of hormonal endocrine with motion sickness and antimotion sickness, and afford a new theoretical basis for the prevention of motion sickness. Method: Conditioned taste aversion, as an index of motion sickness in rats, was induced by rotatory stimulation, and plasma cortisol level was then analyzed with radioimmunoassay. Meanwhile, we observed the antimotion sickness effect of compound ginger extracts (1. 8ml/200g, p. o.) and their influence on plasma cortisol level. Results: The plasma cortisol level tended to elevate after rotatory stimulation, compound ginger extracts prevented motion sickness and raised plasma cortisol level furthermore. Conclusion: Motion sickness is not a simple stress response, its development may relate to the disorder of endocrine induced by abnormal motion stimulation. Therefore, prevention of motion sickness could attain by way of changing endocrine functions.