摘要
急性髓系白血病(acute myeloidleukemia,AML)是一组起源于造血干细胞的恶性克隆性疾病,具有高度异质性。细胞遗传学是AML患者最重要的独立预后指标之一,依据常规染色体检测和荧光原位杂交(FISH)技术分析,发现50%的成人AML患者有重现性染色体数目和/或结构异常。
出处
《现代实用医学》
2010年第9期1071-1075,共5页
Modern Practical Medicine
参考文献10
-
1Mrózek K,Marcucci G,Paschka P,et al.Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics:are we ready for a prognostically prioritized mol-ecular classification-[].Blood.2007
-
2Schlenk RF,DohnerK,KrauterJ,et al.Mut-ations and treatment outcome in cytogene-tically normal acute myeloid leukemia[].The New England Journal of Medicine.2008
-
3Baldus CD,Mrózek K,Marcucci G,et al.Clinical outcome of de novo acute myeloidleukemia patients with normal cytogenetics is affected by moleculargenetic alterations:a concise review[].British Journal of Ha-ematology.2007
-
4Kayser S,Schlenk RF,Londono MC,et al.Insertion of FLT3internal tandem duplic-ation in the tyrosine kinase domain-1is as-sociated with resistance to chemotherapy and inferior outcome[].Blood.2009
-
5Schlenk RF,DohnerK.Impactofnewprog-nostic markers in treatment detections in acute myeloid leukemia[].Current Opinion in Hematology.2009
-
6Renneville A,Roumier C,Biggio V,et al.Cooperatinggenemutationsinacutemyeloid leukemia:areview oftheliterature[].Leukemia.2008
-
7MauniN,AlcalayM.Roleofnucleophosmin in acute myeloid leukemia[].Expert Review of Anticancer Therapy.2009
-
8Verhaak RGW,Goudswaard CS,Putten Wv,et al.Mutations in nucleophosmin(NPM1)inacutemyeloidleukemia(AML):association with other geneabnormalities and previously established gene expression signatures and their favorable prognostic significance[].Blood.2005
-
9GaleRE,GreenC,Allen C,et al.The impact of Flt3internal tandem duplication mutant level,number,size,and interaction with NPM1mutations in a large cohort of young adult patients with acute myeloid leukemia[].Blood.2008
-
10Thiede C,Koch S,Creutzig E,et al.Preva-lence and prognostic impact of NPM1mut-ationsin1485adultpatientswith acutemyeloid leukemia(AML)[].Blood.2006
同被引文献2
-
1石红霞,江滨,丘镜莹,卢锡京,傅剑锋,王德炳,陆道培.成人t(8;21)急性髓系白血病M2型治疗方案及预后分析[J].中华血液学杂志,2005,26(8):481-484. 被引量:19
-
2谢惠敏,高丽,王楠,徐媛媛,石金龙,于力,王莉莉.AML1/ETO阳性急性髓系白血病患者FLT3基因高表达及其临床意义[J].中国实验血液学杂志,2014,22(5):1199-1205. 被引量:12
引证文献1
-
1宫丹,李薇,胡亮钉,罗建民,沈建良,方美云,杨清明,王恒湘,克晓燕,陈惠仁,王昭,刘辉,刘峰,马一盖,王景文,李红华,王全顺,靖彧,高晓宁,窦丽萍,李永辉,于力.中国t(8;21)AML患者临床特征及预后分析:一项多中心回顾性研究[J].中国实验血液学杂志,2017,25(4):980-986. 被引量:7
二级引证文献7
-
1陈月苗,俞康,郑翠苹,周文锦,刘珍.CD56阳性对急性早幼粒细胞白血病患者预后的影响[J].温州医科大学学报,2019,49(2):96-99. 被引量:3
-
2于景秋,薛胜利,李正,王隽,王超,储小玲,撖荣,陶涛,邱桥成,吴德沛.二代测序检测克隆性基因突变对RUNX1-RUNX1T1阳性急性髓系白血病的预后价值[J].中华血液学杂志,2020,41(3):210-215. 被引量:3
-
3王伟伟,徐元宏.免疫表型及非髓系分化抗原表达分析:对急性髓细胞白血病的诊断和预后判定有应用价值[J].南方医科大学学报,2020,40(11):1639-1644. 被引量:8
-
4王晚霞,李敬东.淋系抗原表达对急性髓系白血病预后的价值[J].现代肿瘤医学,2022,30(9):1667-1671. 被引量:2
-
5刘丹,李建英,王庚,吴卫.因血常规MCHC增高行镜检发现急性髓系白血病1例报道[J].检验医学,2023,38(8):805-806.
-
6周文华,陈国安.t(8;21)急性髓系白血病预后因素研究进展[J].中华实用诊断与治疗杂志,2019,33(2):197-200. 被引量:8
-
7荣岩岩.伴附加染色体异常t(8;21)AML预后的研究进展[J].世界最新医学信息文摘,2019,0(26):104-105. 被引量:2
-
1李海明,王春燕,于宝丹,郑润辉,刘丹,汪涯雅,黄振倩,谭获.37例慢性淋巴细胞白血病临床分析[J].黑龙江医学,2016,40(5):437-438. 被引量:2
-
2沈孛.染色体检测在慢性粒细胞白血病诊断中的意义[J].陕西医学杂志,2001,30(10):617-618.
-
3孟小莉,王云贵,叶王秀锦,陈志妹,林茂芳.急性早幼粒细胞白血病PML-RARα融合基因的检测及其临床意义[J].实用肿瘤杂志,2001,16(4):248-249. 被引量:1
-
4杨科,黄凌燕.荧光原位杂交技术在急性淋巴细胞白血病异常染色体检测中的应用[J].中华医学杂志,1998,78(10):787-788.
-
5伍宏彪,吴巨钢,姜波健,俞继卫.胃癌预后相关基因及其表达产物的研究进展[J].腹部外科,2008,21(5):317-318.
-
6曲国蕃,孙志海,李佳慧.与骨肉瘤预后相关的基因研究进展[J].基础医学与临床,2006,26(10):1157-1160. 被引量:1
-
7刘夏(综述),卢振霞(审校).基因芯片技术在乳腺癌化疗和预后中的应用[J].国际肿瘤学杂志,2008,35(1):27-30.
-
8郑鹏举,范宗宪,姚雅芬.鼻内翻性乳头状瘤预后相关基因表达及临床意义[J].中国误诊学杂志,2007,7(27):6528-6529. 被引量:3
-
9林圣云,虞荣喜,罗秀素,周郁鸿,胡致平.继发性急性非淋巴细胞白血病的染色体检测和预后[J].白血病,1999,8(2):111-112.
-
10刘玥,马文丽,孟凡义,郑文岭.急性粒细胞白血病基因表达谱的研究[J].解放军医学杂志,2006,31(4):312-315.