硒和维生素E对糖尿病大鼠氧化和非酶糖化的影响

EFFECT OF SELENIUM AND VITAMIN E ON OXIDATIONAND NONENZYMATIC GLYCATION IN DIABETIC RATS

探讨硒（Ｓｅ）和／或维生素Ｅ（ＶＥ）对氧化和非酶糖化作用的影响。方法：观察链脲佐菌素（ＳＴＺ）糖尿病大鼠喂饲Ｓｅ和／或ＶＥ后，糖化低密度脂蛋白（Ｇ－ＬＤＬ）、糖化血红蛋白（ＧＨｂ）、脂质过氧化产物丙二醛（ＭＤＡ）的含量以及超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性的改变。结果：喂饲Ｓｅ和／或ＶＥ的病鼠与未喂饲Ｓｅ和／或ＶＥ的病鼠比较，Ｇ－ＬＤＬ和ＧＨｂ水平显著下降（Ｐ＜０．０１），ＳＯＤ和ＧＳＨ－Ｐｘ的活性有不同程度升高，ＭＤＡ含量下降（Ｐ＜０．０１）。结论：Ｓｅ和／或ＶＥ对ＬＤＬ和Ｈｂ的非酶糖化有明显的抑制作用，同时，糖尿病大鼠体内的抗氧化能力也显著增强，从而有利于延缓糖尿病慢性血管病变的发生和发展。

Abstract Objective: To investigate the effect of Se and VE on oxidation and nonenzymatic glycation in STZ diabetic rats． Methods: The changes of GLDL、GHb、MDA and SOD、GSHPx in STZ diabetic rats fed with selenium and vitamin E were measured． Results: It was found that the GLDL、GHb、MDA levels decreased （P<001） and the SOD、GSHPx activities increased in the treated diabetic rats as compared with those in the untreated diabetic rats． Conclusion: These results suggest that selenium and vitamin E are effective in inhibiting the nonenzymatic glycation of LDL、Hb and enhancing the antioxidation capacity in diabetic rats， thereby exert favourable effect against the occurrence and development of chronic vascular complications in diabetic mellitus． Key words: selenium vitamin E diabetic mellitus nonenzymatic glycation oxidation