TGF-β1-509C/T基因多态性与胃十二指肠疾病幽门螺杆菌感染的关系

Association of Transforming Growth Factor Beta 1 Gene Polymorphism and Gastroauodenal Diseases with Helicobaeter Pylori Infection

目的研究TGF-β1基因-509位点C/T多态性与胃十二指肠疾病易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性方法,检测40例慢性胃炎,38例消化性溃疡,62例非贲门胃癌患者和102例正常对照者TGF-β1基因-509位点C/T等位基因及基因型分布,并对该基因多态性与幽门螺杆菌感染的相关性进行分析。结果 TGF-β1等位基因频率及基因型频率在病例组和对照组的分布无显著性差异;将胃十二指肠疾病患者按幽门螺杆菌感染分层后,结果提示TGF-β1基因型及等位基因频率分布无显著性差异。结论 TGF-β1-509位点基因多态性与胃十二指肠疾病幽门螺杆菌感染无关。

Objective To study the distribution of transforming growth factor beta 1 gene - 509 bpolymorphism and the association with Chinese patients with gastroduodenal diseases. Methods 140 patients with gastroduodenal diseases （50 chronic gastritis, 38 gastroduodenal ulcer and 62 non-cardia gastric cancer） and 102 healthy controls were collected from unrelated Chinese Han population in Guangdong province. Transforming growth factor beta 1 -509 polymorphism was genotyped by polymerase chain reaction - restriction fragment length polymorphism. Association of the genotype and allele frequencies was studied with helicobacter pylori infection. Results There were not overall significant differences in genotype and allele frequency between the gastroduodenal diseases and the controls. Alter subgroup gastroduodenal diseases into helicobacter pylori infection, the distribution of transforming growth factor beta 1 gene -509 polymorphism was not significantly different. Conclusion Trans- forming growth factor beta 1 gene -509 polymorphism did not associate with gastroduodenal diseases with helicobacter pylori infection.