十二指肠间质瘤临床分析

Clinical Analysis of Duodenal Gastrointestinal Stromal Tumors

目的探讨十二指肠间质瘤的临床特点、诊断手段及治疗方法。方法回顾性分析我院2003年1月～2010年1月收治的16例十二指肠间质瘤的临床资料。结果本组患者以上消化道出血、腹部包块及上腹隐痛不适为常见症状,发病部位以降部和球部多见,分别经内镜、上消化道钡餐及上腹CT或MRI检查诊断本病。免疫组化检测示:CD117阳性15例,CD34阳性10例,S-100阳性4例,Actin阳性5例。所有患者均行手术切除肿瘤,预后良好。结论十二指肠间质瘤临床表现无特异性,合理选择内镜及影像学检查可以提高检出率。组织病理学及免疫组化检查是确诊手段。早期根治性手术是首选的治疗方法。

Objective To investigate the clinical characteristics, diagnosis and treatment of duodenal gastrointestinal stromal tumors （GISTs）. Methods The clinical data of 16 patients with duodenal GISTs from 2003.1 to 2010.1 in our hospital were retrospectively analyzed. Results The symptoms of duodenal GISTs were upper gastrointestinal hemorrhage, abdominal mass and abdominal pain. The lesions were mainly located in descending portion and bulb. The diagnoses were performed by endoscopy, upper gastrointestinal barium meal examination and CT or MRI scan . Immunohistochemical results were showed as following： 15 cases were positive for CD 117, 10 cases were positive for CD 34 , 4 cases stained with the S-100 protein, 5 cases were positive for actin. All patients underwent surgical resection of tumor, and the prognoses were good. Conclusions patients with duodenal GISTs are lack of specific symptoms and signs. Endoscopy and imageology may be helpful for diagnosis. Histopathological and immunohistochemical examination are the main means of definite diagnosis. Surgical resection is the first choice.