高IgE血症和平山病相关性研究

Study of association between hyperlgEaemia and Hirayama disease

目的 明确高IgE血症是否与平山病相关.方法 对2006至2009年期间经门诊确诊的123例平山病患者和82例对照检测血总IgE,收集临床资料,评估临床的特征.正态分布的计量资料采用t检验,非正态分布的计量资料采用非参数检验,计数资料采用卡方检验.结果 14例患者（11.4%）和11例对照（13.4%）既往或现病史有过敏史.平山病组血总IgE的中位数为87.97IU/ml,对照组为59.21 IU/ml,正常对照的中位数为51.39 IU/ml,平山病组与对照组、正常对照之间的差异无统计学意义（P值分别为0.344,0.361）.57例患者（43.6%）和30例对照（36.6%）出现血IgE升高（P=0.107）,29例患者（23.6%）和13例对照（15.9%）为高IgE血症（P=0.121）.但病例组和对照组相比,差异均无统计学意义.按病程长短、疾病严重程度分层后,也没有发现IgE异常和高IgE血症在组间有差异有统计学意义.结论 不管病程的长短、疾病的严重程度,IgE水平在平山病组和对照组之间差异无统计学意义.高IgE血症和平山病无明显相关性.

Objective To investigate whether hyperIgEaemia is associated with Hirayama disease in China. Methods Serum total IgE were examined in 123 patients and 82 control subjects from 2006 to 2009at this hospital and their correlations with clinical profiles investigated. The data were analyzed by t, Chisquare and nonparametric tests. Results Past or present history of allergy/atopy was found in 14 （ 11.4% ）patients and 11 （ 13.4% ）controls. The median value of serum total IgE were 87.97, 59.21 and 51.39 IU/ml in patients, controls and health controls respectively. There were no significant difference between the patient and control groups （ Z = - 0.947, P = 0. 344 ） and the health control groups （ Z = - 0. 914, P =0. 361 ）. Serum IgE was elevated in 57 （43.6%） patients and 30 （ 36.6% ） controls. HyperIgEaemia was present in 29 （ 23.6% ） patients and 13 （ 15.9% ） controls. There was no significant difference in the frequency of history of allergy/atopy, IgE elevation or hyperIgEaemia （ P 〉 0. 05 ） between cases and controls. Even after analyzing the length of duration or the severity of clinical disabilities, there was no difference neither （ P 〉 0.05 ）. Conclusion Whether the length of duration or the severity of clinical disabilities, the serum total IgE level has no significant difference between all groups. HyperIgEaemia is not associated with Hirayama disease.