胰高血糖素样肽-1及其类似物抗胰岛β细胞凋亡作用及机制的研究进展

Effects and mechanisms of glucagon like peptide-1(GLP-1) and its mimetics on the apoptosis of β cells

胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)及其类似物通过提高增殖、减少凋亡,从而有效地保护β细胞数量及功能。该文综述了GLP-1及其类似物能够对抗引起β细胞凋亡的多种有害因素——如细胞因子(IL-1β、TNF-α和IFN-γ等)、高游离脂肪酸血症、高血糖或低血糖等——进而降低胰岛β细胞的凋亡率,并探讨了相关的作用机制。

Glucagon-like peptide-1（GLP-1） and its mimetic exhibit positive effects on β cell mass by both inceasing proliferation and decreasing apoptosis.Here we review the effects of GLP-1 and its mimetics on apoptosis caused by increased cytokines,glucose inbalance and lipotoxicity shown in both type 1 and type 2 diabetes.Studies in rodents,cell lines and isolated β cells are also analyzed in order to understand the mechanisms associated with the effects.