室管膜下区神经干细胞与神经发生的研究进展

Recent research on neural stem cells and neurogenesis of subventricular zone

室管膜下区(subventricular zone,SVZ)存在着神经干细胞(nueral stem cells,NSCs),是成年哺乳动物脑内重要的神经发生区域。神经发生过程极为复杂,包括一系列的生物学事件。在病理状态下,SVZ区的细胞增殖,新生的神经细胞迁移到病灶处,取代或修复受损的细胞,起到保护脑组织的作用。该文就SVZ区的神经干细胞、神经发生过程及病理状态下神经发生的相关研究做一综述。

Neural stem cells persist in the subventricular zone,which is a main area of neurogenesis in adult mammalian brain.The process of neurogenesis is extremely complex,including a series of biological events.Under the pathological conditions,the cells in subependymal zone can proliferate and newborn neurons migrate to the lesions,where they replace or repair the damaged cells,playing a role in protecting brain.Here,after describing the neural stem cells and its character,we review recent advances in the process of neurogenesis in subependymal zone and its changes in pathological states.