甲胎蛋白在原发性肝癌诊断中的临床价值

目的评价血清甲胎蛋白(AFP)在原发性肝癌(HCC)诊断中的临床价值。方法分析从2009年6月～2010年7月进行的活检病理结果中确诊为原发性肝癌的73例患者的血清AFP水平,以及41例肝硬化患者及33例正常体检者的AFP水平。分析血清甲胎蛋白水平与肿瘤TNM分期之间的关系。结果 AFP在原发性肝癌组病人中的水平高于肝硬化组及正常对照组,差异有统计学意义。血清AFP水平在不同TNM分期之间有统计学差异,且随着肿瘤增大数值增高。AFP检测对于原发性肝癌的敏感性、特异性分别为69.9%、87.8%。结论血清AFP在原发性肝癌的检测中具有重要临床意义。

Objective To evaluate the value of serum alpfa-fetoprotein（AFP） in the diagnosis of hepatocellular carcinoma （HCC）.Methods Serum AFP was studied in 73 patients with HCC, 41 patients with cirrhosis, and 33 controls. To analysis the relation between value of AFP activity and TNM staging. Results AFP was incresed in 51 of 73 （69.9%） patients. The positive rate was statistically different from that in patients with cirrhosis, and that in normal individual. The AFP level was correlated with TNM stage. The positive rate of AFP in HCC patients was 69.9%. Conclusion AFP is a useful marker of HCC for diagnosis and posttreatment monitoring.