甲氨蝶呤治疗异位妊娠疗效观察

目的探讨甲氨蝶呤用于治疗异位妊娠的效果。方法选择异位妊娠患者70例,随机分为治疗组和对照组各35例。两组患者一般状况具有可比性。对照组应用米非司酮口服;治疗组应用甲氨蝶呤肌内注射的同时,口服米非司酮。4天为一个疗程。所有患者根据情况治疗2～3个疗程。服药1～3个疗程后,分别检测血β—HCG及盆腔B超孕卵的变化情况,并观察两组患者的治疗效果。结果治疗组治愈31例,治愈率为88.57%,对照组治愈26例,治愈率为74.29%,两者比较差异有统计学意义,甲氨蝶呤联合米非司酮治疗异位妊娠的效果优于米非司酮。两个疗程后,两组患者血β—HCG开始明显下降,孕卵缩小,与治疗前比较,差异有统计学意义。但治疗组患者上述症状改善更明显。结论甲氨蝶呤联合米非司酮治疗异位妊娠的效果优于米非司酮。患者能够保留生育功能,且无明显不良反应发生,治疗方便,作为保守治疗药物,有一定的临床意义和应用前景。

Objective To explore the Effect ofmethotrexate treatment of ectopic pregnancy. Methods Selected 70 patients with ectopic pregnancy, randomly divided into treatment group and control group, 35 patients in each group. General state of the two groups were comparable. The control group were treated with mifepristone; patients in treatment group, while intramuscular injection of methotrexate, oral mifepristone. 4 days as a course. All patients were treated according to the situation 2 to 3 courses. Medication after 1 to 3 courses, respectively, of serum [~ -HCG and pelvic B-fecundity changes, and patient outcomes were observed.Results Treatment group, 31 cases were cured, the cure rate was 88.57%, control group, 26 cases were cured, the cure rate was 74.29%, the difference was statistically significant, methotrexate ectopic pregnancy is better than？mifepristone.After two treatments, two groups of serum I~ -HCG began to significantly decreased fecundity reduced compared with that before treatment, the difference was statistically significant.However, treatment group patients symptoms treated more obvious. Conclusion Methotrexate ectopic pregnancy is better than mifepristone.To preserve fertility in patients with no evidence of adverse events, treatment convenience, as conservative treatments, there are certain clinical significance and applications.