血清肝纤维化指标在慢性肝病诊断中的应用

目的探讨联合测定血清透明质酸(HA)、层粘蛋白(LN)、Ⅲ型前胶原(PCⅢ)及Ⅳ型胶原(Ⅳ-C)对慢性肝病肝纤维化的诊断意义。方法采用放射免疫分析法检测106例慢性肝病患者的HA、LN、PCⅢ、Ⅳ-C,并与25例健康者对比。结果各组肝病四项纤维化指标较健康对照组有升高,肝硬化病人的4项指标较其他各组明显增高。结论 4项指标HA、LN、PCⅢ及Ⅳ-C的联合测定有助于慢性肝病肝纤维化的诊断,适合于动态观察肝病的进展,对肝病的预后具有一定的指导意义。

Objective To investigate the significance of combined testing aminoterminal propeptide of hyalurnoic acid （HA）,laminin （LN）,precollagen type Ⅲ（PC Ⅲ） and collagen type Ⅳ（Ⅳ-C）in the chronic hepatitis with hepatic fibrosis. Methods Serum HA,LN,PC Ⅲ,Ⅳ-C of 106 patients with hepatic disease were examined by radioimmunoassay and the resuits were compared with those of 25 healthy people. Results Four fibrosis indices of liver disease in each group had increased than the control group, and the four indicators in cirrhosis patients were higher than the other groups. Conclusion Combined testing HA, LN,PC Ⅲ and Ⅳ-C is useful for diagnosis of hepatic fibrosis in chronic liver disease, and suitable for dynamic observation of the progress of hepatic disease. It is guide significance for prognosis of hepatic disease.