新生儿缺氧缺血性脑病患者血浆胰岛素、神经肽Y水平检测的临床意义

目的探讨新生儿缺氧缺血性脑病患者血浆胰岛素(Ins)、神经肽Y(NPY)水平的变化及临床意义。方法应用放射免疫分析法测定了94例新生儿缺氧缺血性脑病患者血清胰岛素和神经肽Y水平,并与30名正常新生儿作比较,进行相关性分析。结果新生儿缺氧缺血性脑病患者血浆胰岛素和神经肽Y水平均显著的高于正常新生儿组(P<0.01),且两者呈明显正相关(r=0.6112,P<0.01)。结论新生儿缺氧缺血性脑病患者血浆胰岛素和神经肽Y水平的变化与疾病的危重程度发生发展及预后密切相关。

Objective To investigate the contents of plasma Ins and NPY levels in patients with newborn hypoxic—Ischemicencephalopathy（HIE） babies in various clinic staes and their clinical significance. Methods The plasma levels of Ins and NPY of 94 HIE babies and 30 controls were determined by RIA and the values were studied for different clinical stages. Results Plasma Ins and NPY levels were higer than those in controls （P0.01） in patients with newborn hypoxic—Ischemic encephalopathy .There are positive correlation of Ins and NPY.Conclusion Determination of plasma Ins and NPY levels in NIE neonates were correlated to the clinic stage and severeness of the disease.