类风湿性关节炎患者血脂分析

目的测定类风湿性关节炎(RA)患者血脂水平,探讨其与RA血清学指标以及疾病活动的关系。方法研究对象共92例,其中实验组为RA患者62例,正常对照组30例。测定两组类风湿因子(RF)、血沉(ESR)、C反应蛋白(CRP)、抗环瓜氨酸抗体(ACCP)以及总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、载脂蛋白A1(Apo-A1)、载脂蛋白B(Apo-B)及脂蛋白(a)[LP(a)];应用疾病活动性评分(DAS28)评定RA患者疾病活动度。结果 RA患者TG、LP(a)高于正常对照组(P<0.05),而HDL-C、APO-A1低于正常对照组(P<0.05)。LP(a)与ESR、DAS28评分呈正相关。结论 RA患者血脂LP(a)测定可能对RA疾病活动性评估具有一定意义,并且可解释RA患者与心血管疾病关系。

Objective To investigate the progression of the lipid profile in people developed rheumatoid arthritis and analysis the correlation between the changes of serum lipids in rheumatoid arthritis（RA） and disease active index. Methods Levels of total cholesterol, high-density lipoprotein cholesterol （HDLc）, triglycerides, apolipoproteinAl （apo AI）, apolipoprotein B （apo B） and lipoprotein（a） （Lp（a）） were assayed in 62 rheumatoid arthritis, as well as disease active index（DAS）, rheumatoid factor （RF）, erythrocyte sedimentation rate （ESR） ,C reactive protein （CRP） and anti-cyclic citrullinated peptide antibody. These samples were compared with 30 control samples of unselectedblood donors, matched for age, sex and storage time.Results Samples of patients with rheumatoid arthritis showed higher triglyceride and higher lp（a）levels than matched controls,lower high-density lipoprotein cholesterol and lower apolipoproteinAl than controls.lp（a）and ESR,DAS28 were positivly correlated （P 〈0.05）. Conclusion The level of LP （a） may indicate the disease activity of RA, and can explain the relation of RA with cardiovascular diseases.