10日序贯疗法根除幽门螺杆菌的临床观察

Clinical observation of 10-days sequential treatment to eradicate helicobacter pylori

目的 比较10日序贯疗法与传统三联疗法根除幽门螺杆菌（Hp）的疗效.方法 选取14C尿素呼气试验阳性或者胃镜活组织检查Hp阳性病例90例,随机分为两组：治疗组前5 d予雷贝拉唑、阿莫西林,后5 d予雷贝拉唑、替硝唑、左氧氟沙星治疗;对照组予雷贝拉唑、阿莫西林、克拉霉素（三联疗法）治疗10 d.疗程结束1月后行14C尿素呼气试验检测.结果 治疗组Hp根除率为93.3%,对照组根除率为75.6%,两组Hp根除率差异有统计学意义（P＜0.05）.结论 与传统三联疗法比较,以雷贝拉唑、左氧氟沙星等组成的10日序贯疗法治疗Hp感染具有较高的根除率.

Objective To compare the efficacy of 10-days sequential treatment（ including rabeprazole,amoxillin, levofloxacin and tinidazole） and traditional trigeminy therapy （including rabeprazole, amoxillin and clarithromy-cin） for the eradication of helicobacter pylori （ Hp）. Methods 90 patients with Hp positive who were detected by 14C urea breath test or gastroscope Hp test were randomly divided into two groups： the therapeutic group and the control group. The therapeutic group was treated with rabeprazole,amoxillin at first 5 days,rabeprazole,levofloxacin and tinidazole at the second 5 days,while the control group was treated with rabeprazole,amoxillin and clarithromycin for 10 days. The 14C urea breath test was detected after course of treatment finished in a month. Results The eradication rate of 10 days sequential treatment was 93. 3% and that of control group was 75. 6% ,and the difference between two groups was significant（P 〈0.05）. Conclusion Comparing with traditional trigeminy therapy,the 10-days sequential treatment comprising rabeprazole and levofloxacin could achieve a higher eradication rate of Hp.