摘要
1,3-丁二烯是卷烟烟气中重要有害成分,其在人体内产生的代谢物和加合物,如3,4-二羟基硫尿酸、1-羟甲基-2-苯硫酚尿酸、N-(2-羟基-3-正丁巴比妥)缬氨酸和N-(2,3,4-三羟基丁基)缬氨酸等,可作为1,3-丁二烯接触生物标记物用于区分不同暴露剂量人群(如吸烟者和非吸烟者,职业暴露和普通人群)及预测可能的作用机制。本文对1,3-丁二烯的流行病学、致癌性、遗传毒理学、代谢途径及其接触生物标记物的研究进展进行综述,并从1,3-丁二烯生物标记物存在的问题和研究现状出发,对其在感受烟气和普通人群进行生物监测中的应用进行了展望。
1,3-butadiene,a main toxic chemical in tobacco smoking,is a probable carcinogen to humans.Environmental exposure to 1,3-butadiene resulted in increases in body burden reflected in various biomarkers,including urinary 1,2-dihydroxybutyl mercapturic acid,monohydroxy-3-butenyl mercapturic acids,1,2-hydroxy-3-butenyl valine adducts,and N-（2,3,4-Trihydroxybutyl） valine in hemoglobin.Literature indicates that biomarkers can be used to distinguish populations with different levels of exposure （such as smokers from nonsmokers and occupationally exposed from general population） and to determine differences in metabolism.Current investigation of metabolism,epidemiology,carcinogenicity,genotoxicity and biomarkers of 1,3-butadiene were reviewed.Prospects of applying 1,3-butadiene biomarkers in biological monitoring in smokers and to study general population were reviewed.
出处
《中国烟草学报》
EI
CAS
CSCD
2010年第5期89-94,共6页
Acta Tabacaria Sinica
