益心舒胶囊对急性冠脉综合征患者炎性因子的影响

Influence of Yixinshu Capsule on Inflammatory Factors in Acute Coronary Syndrome

目的观察益心舒胶囊对急性冠脉综合征(ACS)患者血清炎性因子的影响。方法收集206例ACS患者,随机分为对照组(102例)和治疗组(104例)。两组均予常规治疗,治疗组加服益心舒胶囊9粒/天。用酶联免疫吸附法分别检测两组患者治疗前后血浆C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平。结果与治疗前相比,治疗组治疗后CRP降低了0.9 1 mg/L±2.1 8 mg/L,差异具有统计学意义(P<0.0 1);TNF-α降低2 5 4 ng/L±7 5 5 ng/L,IL-6降低0.0 5 ng/L±0.1 7ng/L,治疗前后比较有统计学意义(P<0.05)。对照组各项指标治疗前后比较无统计学意义。结论益心舒胶囊的抗炎和稳定斑块作用在治疗ACS发挥着重要作用。

Objective To observe the influence of yixinshu capsule on serum inflammatory factors in patients（pts） with acute coronary syndrome（ACS）.Methods Two hundreds and six pts with ACS were randomized into two groups：Control group（n=102） treated with routine treatment,treatment group（n=104） treated with Yixinshu capsule and routine treatment.The concentration of serum C-reactive protein（CRP）,tumor necrosis factor α（TNF-α） and interleukin-6（IL-6） were measured by enzyme-linked immunosorbent assay（ELISA）.Results After treatment,the concentration of serum CRP,TNF-α and IL-6 were decreased significantly in treatment group（P0.05 or P0.01）.Condusion Yixinshu capsule had effect on anti-inflammation and stabilizing atherosclerotic plaques.