摘要
目的 探讨家兔慢性心力衰竭（心衰）时心肌肌浆网钙泵（SERCA2）表达和功能的改变.方法 14只家兔随机分为2组,假手术组和心衰组各7只.通过超容量负荷联合压力负荷建立家兔心衰模型.于术后7周观察左心室结构、血流动力学的变化及SERCA2的表达和功能的改变.结果 与假手术组比较,心衰组左心室重量指数（LVMI）、左心室舒张末压显著升高（P〈0.05）,左心室短轴缩短率及左室射血分数明显降低（P〈0.05）;心衰组SERCA2的表达和功能显著低于假手术组（P〈0.05）.结论 心肌SERCA2的表达和功能降低可能是心力衰竭发生因素之一.
Objective To investigate the expression and function of sarcoplasmic retieulum calcium adenodine triphosphatase （SERCA2） in heart failure rabbit. Methods 14 rabbits were divided into two groups：7 rabbits with heart failure induced by volume overload plus pressure overload, 7 sham rabbits. 7 weeks later, left ventricular function, hemodynamic parameters, expression and function of SERCA2 were observed. Results Compared with the sham operated rabbits, LVMI and LVEDP in heart failure rabbits were significandy increased （P〈0.05）, but their left ventricular shorten fraction and ejection fraction were decreased （P〈0.05）. Expression and function of SERCA2 in heart failure rabbits were remarkably lower than sham operated rabbits （P〈0.05）. Conclusion Downregulation of expression and activity of SERCA2 might contribute to risk factors of dysfunction in failing hearts.
出处
《中国心血管病研究》
CAS
2010年第11期856-859,共4页
Chinese Journal of Cardiovascular Research
