化疗栓塞子宫动脉在宫颈癌术前的应用

Preoperative Interventional Chemoembolization for Treatment of Cervical Cancer

目的探讨子宫动脉化疗栓塞在宫颈癌根治术前的临床疗效。方法对2003年2月—2008年11月期间共98例宫颈癌根治术前1个月对子宫动脉进行化疗栓塞。介入术中用化疗药为顺铂,介入术后3d内用化疗药博莱霉素与异环磷酰胺,栓塞剂为超液态碘化油及高压消毒过的明胶海绵颗粒。结果 98例宫颈癌患者经过术前经动脉插管化疗栓塞后顺利经外科手术切除,术后标本病理切片可见大量坏死组织。结论宫颈癌根治术前介入性化疗栓塞可有效缩小肿瘤体积,增加外科手术成功率。

Objective To assess the effectiveness of preoperative interventional chemoembolization in the treatment of cervical cancer and to observe the pathological changes of the tumor after the procedure. Methods During the period of Feb. 2003 - Nov. 2008. preoperative interventional chemoembolization was performed in 98 patients with cervical cancer. The antineoplastic drugs included cisplatin, bleomycin and ifosfamide. In all patients,interventional arterial infusin chemotherapy was carried out befor the embolization of bilateral tumor - feeding arteries with gelfoam was made. Results Totally 98 patients underwent radical resection surgery after 1 time of chemoembolization. Pathologically, massive necrosis and of cervical cancer ymphocytic infiltration were found within the tumor. Conclusion For the treatment the preoperative interventional chemoembolization can effectively decrease the tumor size and reduce blood loss during operation, moreover, even HCR can be obtained in some patients