长疗程聚乙二醇干扰素治疗慢性丙型肝炎的临床研究

Clinical Effects of PEG-IFN and Ribavirin Treatment on Chronic Hepatitis C Patients

目的评价长疗程聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎的临床疗效。方法 45例接受聚乙二醇干扰素α-2b联合利巴韦林治疗未能达到快速应答(rapid virological response,RVR)的慢性丙型肝炎患者被随机分成两组,分别完成聚乙二醇干扰素联合利巴韦林48周治疗(普通疗程组)和72周治疗(长疗程组),在完成治疗后继续随访24周,并观察药物副反应。结果普通疗程组和长疗程组在治疗结束时病毒应答(end treatment virological response,ETVR)分别为(52.1%对77.2%,P(0.05),但是长疗程组持续病毒学应答(sustained virological response,SVR)显著高于普通疗程组(72.7%对34.7%,P<0.05)。结论长疗程聚乙二醇干扰素能够显著提高无快速应答慢性丙肝患者的SVR,副反应随疗程增加未见增加。

Objective To evaluate the clinical effects of PEG - IFN and ribavirin treatment on chronic hepatitis C patients . Methods Totally 45 chronic hepatitis C patients with not get rapidvirological response（RVR） were divided into long period treatment group（72weeks） and normal period treatmen group（48weeks） , All of them were treatment with peginterferonα -2b and ribavirin. Following up studies were conducted at the 24th week after the treatment. Results The response rate of long period treatment group and normal period treatmen group were 52. 1% vs 77.2% respectively aftertreatment, P 〉 0. 05. The continue response rate of long period treatment group and normal period treatmen group were 72.7% vs 34.7% respectively, P 〈 0.05. Conclusion Conclusion Long periodtreatment of PEG - IFN can get better SVR obviously than normal period treatmen group.