摘要
为探索糖尿病型帕金森病的分子机理,利用HPLC-ESI-MS分析了链脲霉素(streptozocin,STZ)诱导的糖尿病大鼠模型与对照大鼠的纹状体、海马区的儿茶酚异喹啉类物质含量的差异。研究发现,糖尿病大鼠纹状体、海马区的1-乙酰基-6,7-二羟基-1,2,3,4-四氢异喹啉(ADTIQ),1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉(Salsolinol,Sal),N-甲基猪毛菜醇(NMSal)的含量升高,其中ADTIQ,Sal的含量升高明显,差异显著。结果提示,糖尿病型帕金森病的病因可能是由于血糖升高,导致脑内醛类物质含量增加,加剧了儿茶酚异喹啉类物质的累积,从而导致线粒体功能缺陷,引起神经元死亡,最终导致帕金森病症状。
Diabetes is a risk factor for Parkinson＇s disease （PD）. There are statistics data indicating that the prevalence of PD among patients with diabetes was higher compared with the normal people. To date,little is known about the molecular events underlying hyperglycemia-induced PD. In this paper,the catechol quinoline substance in corpus striatum （ST） and hippocampus from the brains of diabetic rats model and control rats was analyzed by HPLC- MS. 1-acetyl-6,7-dihyroxy-1,2,3,4- tetrahydro-isoquinoline （ ADTIQ ） and Salsolinol were found significantly elevated compared with control. Microcontent N-methylsalsolinol was found in the brains of diabetic rat model. These results suggested that hyperglycemia will induce the aldehydes to increase and enhance the catechol quinoline substance to accumulate. Thus mitochondrial dysfunction occurred and the neuron died; at last leading diabetes patients to Parkinson＇s disease.
出处
《化学通报》
CAS
CSCD
北大核心
2010年第11期1049-1052,共4页
Chemistry
基金
国家自然科学基金项目(20435020)资助
