摘要
目的初步探讨辅助生殖技术(IVF/ICSI)中异位妊娠(EP)发生的危险因素。方法回顾性分析我院2001年1月-2008年12月接受IVF/ICSI助孕的7798个周期,其中临床妊娠3005个周期(周期妊娠率为38.5%),异位妊娠147个周期(异位妊娠发生率为4.89%),对可能影响正常妊娠导致异位妊娠的因素进行多因素logistic多元回归分析。结果在IVF/ICSI过程中,输卵管积水、促排卵药物使用史、hCG日内膜的厚度、移植胚胎质量与EP的发病明显相关。结论输卵管原因不孕是辅助生殖技术中EP发生的主要相关因素。移植周期合并输卵管积水、既往有输卵管手术史(本治疗周期无输卵管积水)、既往有促排卵药物使用史可增加EP的发生风险;增加hCG日内膜厚度及移植胚胎的质量均可降低IVF/ICSI后EP的发生风险。
Objective：To explore the risk factors associated with ectopic pregnancy after Assisted Reproduction Technologies （ART）.Methods：We retrospectively evaluated all the cycles underwent IVF /ICSI from January 2001 to December 2008.One hundred and forty-six of 3005 pregnancies （4.89%） were ectopic pregnancy,following 7798 IVF /ICSI embryo transfers.Multivariable logistic regression was employed for multi-factor analyses.Results：The infertility associated with tubal factor such as hydrosalpinx,past medical history of controlled ovarian hyperstimulation （COH）,the thickness of endometrium before hCG injection,the quality of transplanted embryos was correlated with ectopic pregnancy.Conclusion：The infertility associated with tubal factor is the main correlative factor with EP in IVF /ICSI programs;hydrosalpinx,past medical history of COH can increase the risk of ectopic pregnancy;on the other hand,increase the endometrium＇s thickness and the quality of transplanted embryo will decrease the risk.
出处
《中国优生与遗传杂志》
2010年第11期118-120,共3页
Chinese Journal of Birth Health & Heredity
