盐酸戊乙奎醚对慢性阻塞性肺病患者血流动力学和微循环的影响

The effect of penehyclidine hydrochloride on hemodynamics and microcirculation in patients with chronic obstructive pulmonary disease

目的观察盐酸戊乙奎醚对慢性阻塞性肺病(COPD)患者血流动力学和微循环的影响。方法 40例慢性阻塞性肺病患者均给予气管插管呼吸机辅助呼吸,随机分为两组,盐酸戊乙奎醚组(Ⅰ组):每12小时静注盐酸戊乙奎醚1mg;氨茶碱组(Ⅱ组):氨茶碱持续泵入0.6mg·kg-1.min-1。分别监测用药后2、4和6h的BP、HR和体温、血乳酸(ABL)含量、尿量。结果两组患者血流动力学差异无统计学意义。与Ⅱ组比较,用药后4、6hⅠ组体温升高(P<0.05),ABL含量降低(P<0.05),尿量增多(P<0.05)。结论盐酸戊乙奎醚应用于COPD患者不会引起血流动力学的改变;对微循环有明显改善。

Objective To observe the effect of penehyclidine hydrochloride on hemodynamics and microeirculation in patients with chronic obstructive pulmonary disease（COPD）. Methods Forty patients with COPD were randomly divided into two groups. Group Ⅰ（penehyclidine hydrochloride） patients were injected 1 mg of penehyclidine hydrochloride evrey 12 hours; group Ⅱ （aminophylline） patients continuous infusioned aminophylline 0.6 mg·kg^-1·min^-1. Hemodynamic parameters （BP, HR, CVP） and microcirculation index （body temperature, lactic acid, urine） were measured in 2, 4 and 6 hour after tracheal intuhation. Results Hemodynamic parameters of the two groups were not significantly different. Patients in group I had significant higher body temperature, lower lactic acid and more urine than group Ⅱ （P〈0. 05）. Conclusion Penehyclidine hydrochloride used in patients with COPD did not cause hemodynamic changes but could improve microcirculation significantly.