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多功能蛋白AIMP1的生物学活性及其应用前景 被引量：2

Biological activities and application prospects of a multi-functional protein AIMP1
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摘要 氨基酰tRNA合成酶相互作用多功能蛋白质1(aminoacyl-tRNA synthetase-interacting multi-functional protein1,AIMP1)在哺乳动物中最早是被发现作为一种辅助蛋白质参与了一个巨大的氨基酰tRNA合成酶复合物的形成。然而最近越来越多的研究显示,AIMP1还具有多种细胞因子活性,参与到包括免疫调控、血管生成、创伤愈合、血糖稳态,及TGF-β信号途径等多种体内的生理反应。本文着重阐述了AIMP1的多种生物学活性,并且对它的应用前景进行了讨论和展望。 Aminoacyl-tRNA synthetase-interacting multi-functional protein 1 （AIMP1） was first discovered as a factor associated with a large mammalian multi-aminoacyl-tRNA synthetase complex.Recently,accumulating evidences indicated that AIMP1 can be secreted as a cytokine and is involved in the regulation of immune response,angiogenesis,wound healing,glucose homeostasis,and TGF-β signal pathway.Here,we summarize the biological activities of AIMP1,and discuss the therapeutic potential of this multi-functional protein.
作者 胡立德 俞瑜 谭小钉 刘大涛
机构地区 上海信谊药厂有限公司药物研究所 复旦大学生命科学学院
出处 《生命的化学》 CAS CSCD 北大核心 2010年第5期676-679,共4页 Chemistry of Life
关键词 AIMP1 细胞因子 生物学活性 应用前景 AIMP1 cytokine Biological activity application prospect
分类号 Q51 [生物学—生物化学]
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参考文献26

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同被引文献23

  • 1李思发,王强,陈永乐.长江、珠江、黑龙江三水系的鲢、镛、草鱼原种种群的生化遗传结构与变异[J].水产学报,1986,10(4):351-372. 被引量：51
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  • 6Zhu X,Liu Y,Yin Y,et al.MSC p43 required for axonal development in motor neurons [J].Proc Natl Acad Sci U S A,2009,106(37) : 15944-15949.
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  • 10Gustafson B,Hedjazifar S,Gogg S,et al.Insulin resistance and impaired adipogenesis [J].Trends Endocrinol Metab,2015,26 (4):193-200.

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生命的化学
2010年 第5期

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