基于糖链结构的乳腺癌研究

Recent research developments in glycan-based breast cancer

自从Dwek教授提出糖生物学的概念以来,人们逐渐意识到聚糖结构的多变性,并开始重视将糖生物学作为一个新视角为生物医学研究带来的启发。乳腺癌是妇女常见的恶性肿瘤,其发病率正在逐年上升。随着早期诊断及综合治疗方法的改进,患者死亡率有所下降,然而乳腺癌仍然对妇女健康造成了严重威胁。本文从糖链结构的角度,对近年涉及乳腺癌诊断、治疗、预后相关的基于糖链结构的研究作一回顾。

Since Professor Dwek introduced concept of glycobiology,remarkable structural variability of glycan has been gradually recognized,and more and more attention is being paid to glycobiology＇s role as a new perspective for biomedical research.Breast cancer is a malignancy commonly related to women,its incidence rate rises year on year.With the improvements of breast cancer diagnostics and comprehensive treatments,its mortality decreased,but it remains a serious threat to women health.In this article,recent glycan-based breast cancer researches were reviewed concerning clinical fields,such as diagnosis,treatment and prognosis.