与细胞衰老相关的sirtuin家族

Research progress of sirtuins involved in cellular senescence

衰老是发育过程中的普遍现象,是生理功能衰退过程中呈现的一系列特定变化,趋向于疾病发生的复杂过程。细胞衰老是由于端粒缩短、DNA损伤、氧化应激和原癌基因激活中特征分子的改变等产生的一种生理变化。本篇综述通过总结衰老信号通路中的年龄相关基因sirtuins家族与核因子(NF)-κB转录因子家族、p53、FoxO、PGC-1、mTOR等的相互作用,为我们研究衰老进程并在延缓衰老和自然死亡方面提供了可靠的依据。

Aging,one of the pervasive developmental processes,is a complex ensemble of physiological functional decay and a risk factor for many diseases.The mechanism of cellular senescence involves telomere attrition,DNA damage,and characteristic molecular changes in oxidative stress,oncogene activation and so on.In this review,we summarized some significant ageassociated genes in senescence signaling pathway including Sirt family,NF-κB transcription factors,p53,FoxO,PGC-1and mTOR,which are useful to understand the aging process and ultimately postpone ageing and natural death.