水通道蛋白与哮喘

The relationship between aquaporin and asthma

哮喘是全球常见的慢性呼吸道疾病之一,气道炎症细胞积聚、气道慢性炎症和气道高反应性为其三大重要特征。研究发现在哮喘发病过程中,多种炎症细胞、粘膜上皮细胞、肺泡上皮细胞、周围血管内皮细胞等都有水通道蛋白(aquporin,AQP)的异常表达。这些细胞参与哮喘发作时炎症细胞积聚、气道高反应性、粘液异常分泌、肺间质毛细血管通透性改变等多方面反应。AQP在哮喘的发生发展中可能起着重要的作用。在哮喘的诊断方面,除了依据典型的临床症状及支气管激发、舒张实验之外,若AQP在血液嗜酸性粒细胞内或其他组织细胞内的异常表达能作为一种哮喘发病的生化指标,将对哮喘的诊断和防治有突破性的作用。本文就AQP与哮喘的关系进行综述。

Asthma is one of the world＇s common chronic respiratory diseases.Accumulation of airway inflammatory cells,chronic airway inflammation and airway hyperresponsiveness are three important features of asthma.In the pathogenesis of asthma,it has been found that there has obviously abnormal expression of aquaporins （AQPs） in a variety of inflammatory cells,epithelial cells,alveolar epithelial cells and endothelial cells.The cells are involved in the accumulation of inflammatory cells in asthmatic attack,airway hyperresponsiveness,abnormal secretion of mucus,interstitial lung vascular permeability changes and other aspects.AQPs may play an important role in the development of asthma.In the diagnosis of asthma,the abnormal expression of AQPs in EOS of blood and other cells may be as a biochemical marker for asthma,besides typical clinical symptoms,bronchial challenge and relaxation test.In this paper,the relationship between aquaporins and bronchial asthma will be reviewed.