亚健康状态与心血管疾病危险因素关系

Relationship between suboptimal health status and risk factors of cardiovascular diseases

目的探讨亚健康状态与血清皮质醇以及血压、血糖和血脂等心血管疾病危险因素的关系。方法选取首都医科大学附属宣武医院体检中心的健康体检者,进行一般情况和亚健康状态问卷(SHSQ-25)调查,采集静脉血检测血清皮质醇、血糖和血脂相关指标并测量血压;共获得资料完整者812人,以亚健康状态问卷总分≥35分为亚健康组,<35分作为对照组,比较2组人群各检测指标差异,并采用结构方程模型分析亚健康状态与心血管疾病危险因素的关系。结果亚健康组收缩压、空腹血糖、总胆固醇、低密度脂蛋白以及血清皮质醇水平均高于对照组(P<0.05);结构方程模型分析结果表明,亚健康人群应激水平与心血管疾病危险因素存在相关性,拟合指数(GFI)=0.998 8,调整拟合指数(AGFI)=0.993 6,平均残差率的根(RMSR)=0.429 8(95%CI=0.388 3～0.472 8),模型中各通径系数均有统计学意义(P<0.05)。结论亚健康状态与应激及心血管疾病危险因素相关。

Objective To study the relationship between suboptimal health status（SHS） and risk factors of cardiovas-cular disease.Methods The subjects were recruited in Beijing Xuanwu hospital.The suboptimal health status question-naires-25（SHSQ-25） were distributed and the serum cortisol,blood pressure,blood glucose and lipid were measured.The study population was classified into two groups by a total SHSQ-25 score of 35 as the cut-off point.Variance analysis was used to compare serum cortisol,blood pressure,blood glucose and lipid between the two groups.Structural equation model（SEM） was used to confirm the relationships between the variables.Results Among the 812 subjects,the SHS group had a higher level of systolic blood pressure（SBP）,fasting blood glucose（GLU）,total serum cholesterol（TCH） and low density lipoprotein（LDLC） than the control group（P 0.05）.The fit indices shown by the SEM analysis were reasonable with goodness of fit index = 0.998 8,adjusted goodness of fit index = 0.993 6,and residue mean square root = 0.429 8（95% con-fidence interval： 0.388 3,0.472 8）.Conclusion SHS is correlated to some risk factors of cardiovascular disease.