硝苯地平对铁负荷大鼠营养代谢影响

Effects of nifedipine on nutritional metabolism of iron overload rats

目的探讨硝苯地平对铁负荷大鼠营养代谢的影响。方法 30只SD大鼠随机分为对照组、铁负荷组、硝苯地平组(连续7 d腹腔注射硝苯地平),测定血脂、脂质过氧化指标、血清中铁、钙、锌,以及铁蛋白和维生素E含量。结果硝苯地平组大鼠总胆固醇(TC)、低密度脂蛋白(LDL)分别为1.65、0.96 mmol/L,明显低于铁负荷组1.91,1.14 mmol/L,(P<0.05);血清中铁、铁蛋白分别为(1.321±0.148)mg/L,明显低于铁负荷组(1.573±0.253)mg/L(P<0.01),硒含量为(0.087±0.017)mg/L,高于铁负荷组(0.074±0.012)mg/L(P<0.05)。结论硝苯地平影响铁负荷大鼠的营养代谢,降低铁负荷对机体的损害。

Objective To study the effects of nifedipine on nutritional metabolism of iron overload rats.Methods Thirty male SD rats were randomly divided into 3 groups according to their weight（control,iron overload and nifedipine group）.Rats in nifedipine group were treated with peritoneal injection of nifedipine for 7 days continuously.The levels of blood lipid,lipid peroxidation indexes,activities of antioxidant enzymes and contents of serum Fe,ferritin,VE,Fe,Se,and Ca were determined.Results The total cholesterol and low-density lipopotein in rats of nifedipine group were 1.65 and 0.96 mmol/L,and significantly lower than those of rats of iron overload（P 0.05）.And at the same time,the contents of serum Fe and ferritin were 1.321 ± 0.148 and 1.386 ± 0.162 mg /L,and significantly lower than those of to the iron over-load group.But the contents of serum Se in rats of nifedipine group was 0.087 ± 0.017 mg /L and significantly higher than that of the iron overload group.Conclusion Nifedipine can alter the nutritional metabolism and decrease the impact of iron overload in rats.