摘要
目的:考察室温下甘草酸二铵注射液与中性胰岛素注射液在5%葡萄糖注射液、10%葡萄糖注射液中的配伍稳定性。方法:采用高效液相色谱法测定25℃下,甘草酸二铵注射液与中性胰岛素注射液分别在5%、10%葡萄糖注射液中24h内的含量变化,同时考察2组混合液的pH值和外观变化。结果:甘草酸二铵注射液与中性胰岛素注射液在2种溶媒中配伍后,24h内二者含量无明显变化,混合液pH值和外观亦无明显变化,性质稳定。结论:甘草酸二铵注射液与中性胰岛素注射液在5%、10%葡萄糖注射液中可配伍应用。
OBJECTIVE:To investigate the compatibility stability of Diamonium glycyrrhizinate injection combined with Neutral insulin injection in 5% Glucose injection and 10% Glucose injection. METHODS:HPLC method was used to determine the content change of mixture in 5% Glucose injection and 10% Glucose injection at 25 ℃ within 24 h. The pH value and appearance of mixtures were investigated. RESULTS:Appearance,pH value and the content of Diamonium glycyrrhizinate injection combined with Neutral insulin injection in 2 kinds of solvents were stable in 24 hours. CONCLUSION:Diamonium glycyrrhizinate injection can be combined with Neutral insulin injection in 5% Glucose injection and 10% Glucose injection.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第42期3981-3983,共3页
China Pharmacy
关键词
甘草酸二铵注射液
中性胰岛素注射液
葡萄糖注射液
配伍
稳定性
Diamonium glycyrrhizinate injection
Neutral insulin injection
Glucose injection
Compatibility
Stability