PET/CT定位指导下的IMRT与常规放疗对非小细胞肺癌联合同步化疗的临床研究

Clinical research on intensity-modulated radiation therapy (IMRT) positioned by PET/CT and conventional radiotheraphy in chemotherapy of nonsmall cell lung cancer

目的:比较晚期非小细胞肺癌(NSCLC)PET/CT定位指导下的调强适形放疗(IMRT)同步化疗和常规放疗同步化疗的近期疗效和放疗不良反应。方法:对我院放疗中心收治的放疗患者的临床资料进行回顾性分析。PET/CT定位指导下IMRT同步化疗组(实验组)30例,常规放疗同步化疗组(对照组)38例,放疗总剂量达到60 Gy,共6周。结果:实验组总有效率为90.0%,对照组总有效率为57.9%,两组比较,差异有统计学意义(χ2=8.583,P<0.05)。实验组1、2年生存率分别为76.6%、53.3%,对照组1、2年生存率分别为65.8%、44.7%,两组比较,差异无统计学意义(P>0.05)。放射性皮肤反应、放射性食管炎和放射性肺炎两组比较,差异有高度统计学意义(P<0.01)。结论:实验组近期疗效和减少放疗不良反应的发生有明显的优势,而其对生存率的影响,将需待更长时间的随访结果加以明确。

Objective： To compare short-term curative effect and adverse reaction of intensity-modulated radiation therapy（IMRT） positioned by PET/CT and conventional radiotheraphy in advanced non-small cell lung cancer（NSCLC） patients,who accepted chemical-treatment at the same time.Methods： Clinical trail study was carried out in our hospital.The patients who attended the study were divided to two groups,IMRT（experiment group） and conventional radiotheraphy（control group）.There were 30 patients in experiment group and 38 patients in control group.The total dose of radiation were 60 Gy in 6 weeks.Results： There was a significant difference between the curative effect ratio of experiment group（90.0%） and control group（57.9%）（χ^2=8.583,P〈0.05）.The 1,2 years survival rate of experiment group were 76.6% and 53.3%,and the 1,2 years survival rate of control group were 44.7% and 65.8% respectively,there were no significant differences in two groups（P〈0.05）.There were significant differences between the two groups in some adverse reactions such as radioactive skin reactions,radioactive esophagitis and radioactive pneumonia（P〈0.01）.Conclusion： Experiment group has obvious advantages in short-term curative effect and less adverse reactions.As to the survival rate,we need more time to follow-up the results of two groups.