高压氧治疗对新生儿缺氧缺血性脑病血清IL-6及TNF-α的影响

Hyperbaric oxygen therapy influence on serum IL-6 and TNF-α of hypoxic ischemic encephalopathy

目的:探讨高压氧(HBO)治疗新生儿缺氧缺血性脑病(HIE)对血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的影响。方法:将246例新生儿缺氧缺血性脑患儿随机分为常规治疗组和高压氧治疗组,常规治疗组给予常规支持和对症治疗,高压氧治疗组在常规治疗的基础上加用高压氧治疗。比较两组治疗前后的血清IL-6、TNF-α水平的变化。结果:两组治疗前IL-6、TNF-α水平比较差异均无统计学意义。治疗后两组的血清IL-6、TNF-α水平均降低,但高压氧治疗组上述指标下降幅度较常规组明显(P<0.05)。结论:HBO治疗HIE有较好疗效,HBO治疗HIE可能是通过降低IL-6、TNF-α水平而减轻脑细胞损害的。

Objective： To explore hyperbaric oxygen therapy influence on serum IL-6 and TNF-α of hypoxic ischemic encephalopathy.Methods： 246 cases of HIE were randomly divided into conventional treatment group and hyperbaric oxygen therapy group,conventional treatment group was given regular support and symptomatic treatment,while hyperbaric oxygen therapy group given conventional treatment and hyperbaric oxygen therapy.Level change of serum IL-6 and TNF-α was compared before and after the treatment of the two groups.Results： The level of IL-6 and TNF-α had no statistically significant differences before treatment of the two groups.The level of serum IL-6 and TNF-α reduced after treatment in the two groups,but the above indexes in hyperbaric treatment group had significant difference than that in conventional group（P0.05）.Conclusion： HBO therapy on HIE has good curative effect,HBO therapy may reduce level of IL-6 and TNF-α and lighten brain cell damage.